Causes of Leptin Resistance

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Causes of Leptin Resistance

Leptin resistance and obesity are interconnected. When you are overweight, the more body fat you have, the higher your leptin levels go (hyperleptinemia). But having a lot of leptin can make your body less responsive to its signals, and that’s called leptin resistance. 

This lack of leptin sensitivity can lead to continued overeating, causing an accumulation of more body fat and contributing to obesity. While leptin resistance is a factor, it’s essential to understand that various factors, including genetics and lifestyle, also influence obesity.

Other causative factors of leptin resistance are:

  • Inflammation: Inflammatory signalling in your hypothalamus likely causes leptin resistance.
  • Free fatty acids: Higher free fatty acids concentration in the bloodstream interferes with leptin signalling by increasing fat metabolites in the brain.
  • High leptin levels: High leptin levels initially may affect its ability to cross your blood-brain barrier.

Summary

Leptin resistance and obesity go hand-in-hand. When overweight, higher body fat results in increased leptin levels (hyperleptinemia), leading to leptin resistance. This insensitivity contributes to persistent overeating, accumulating more body fat and fostering obesity. Factors like inflammation, elevated free fatty acids, and high leptin levels contribute to leptin resistance by disrupting signalling mechanisms.

Lifestyle Changes to Manage Leptin Resistance

While medication can assist in managing leptin resistance, here are certain lifestyle changes that can be beneficial:

Leptin Resistance Diet

To tackle leptin resistance:

  • Focus on an anti-inflammatory diet.
  • Opt for a balanced mix of fibre-rich foods, veggies, legumes, and quality proteins like wild fish and grass-fed meats.
  • Cut down on fried, processed foods and sugary drinks.
  • Switching to a gluten-free diet may help improve aspects of leptin resistance, like reducing waist circumference, balancing blood sugar, lowering inflammation, and decreasing triglyceride levels.
  • Some people can improve leptin sensitivity through practices like time-restricted eating, calorie restriction, or fasting. 
  • Fasting may help reduce inflammatory markers and reset leptin receptors, promoting weight loss. 

This kind of diet also promotes better weight management and improved overall health. HealthifyMe can tailor a personalised leptin-resistance diet that aligns with your needs. You can also track your progress with the app’s features, making it easier to stick to the diet plan. 

Improve Sleep Cycle

Lack of sufficient sleep, poor sleep habits, and disrupted circadian rhythms increase the risk of leptin resistance. Therefore, improving leptin sensitivity is possible by ensuring adequate sleep. 

To ensure sufficient sleep, establish a consistent bedtime before 10 pm and aim for 7-9 hours of quality rest. 

Regular Exercise

Consistent exercise plays หรือถ้าคุณสนใจแทงบอลออนไลน์ UFABET คือเว็บที่มีอัตราต่อรองดีที่สุดในประเทศไทย สมัครเลยตอนนี้ที่ UFABET แทงบอล a crucial role in reducing body fat, maintaining a healthy weight, and lowering leptin levels. By incorporating regular workouts into your routine, you enhance the body’s capacity to regulate appetite, decrease abdominal obesity, and optimise metabolic health. 

Prioritise a mix of cardiovascular and strength training exercises for maximum benefits. HealthifyMe’s app can assist you in designing a personalised exercise plan, ensuring you meet your fitness goals and promote better weight management.

Supplements

Chinese cinnamon (Cinnamomum cassia) and Gymnema sylvestre are herbs that have the potential to regulate appetite by impacting leptin, glucose, and insulin levels. Incorporating these herbs into your diet, under guidance, may contribute to better appetite control and overall metabolic health. HealthifyMe’s nutrition experts can offer personalised advice on incorporating such herbs into your diet for holistic well-being.